Potassium Periodate Mediated Oxidative Cyclodesulfurization toward Benzofused Nitrogen Heterocycles was written by Duangkamol, Chuthamat;Phakhodee, Wong;Pattarawarapan, Mookda. And the article was included in Synthesis in 2020.Formula: C13H10N2S This article mentions the following:
A convenient method for the synthesis of amino-benzimidazoles/benzoxazoles/benzothiazoles I [R1 = H, 5-Me, 5-Cl, etc.; R2 = Ph, Bn, 4-BrC6H4, etc.; X = NCH2C6H4Me, O, S, etc.] was developed via potassium periodate-mediated oxidative cyclodesulfurization of isothiocyanates with ortho-substituted anilines bearing N,N-, N,O-, and N,S-bis-nucleophiles, followed by an intramol. cyclization of the in situ generated monothioureas in good to excellent yields. The protocol could accommodate various substituents on both substrates while allowing more efficient, greener and operational simpler process relative to other oxidative coupling reactions. Tetracyclic quinazolinone derivatives II [R3 = H, 8-Me, 9-Me, 9-Cl] were also afforded in high yields in a single preparative step and chromatog.-free. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Formula: C13H10N2S).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Formula: C13H10N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica