Synthesis and biological evaluation of alkyl, alkoxy, alkylthio, or amino-substituted 2,3-dihydro-1,5-benzothiazepin-4(5H)-ones was written by Inoue, Hirozumi;Konda, Mikihiko;Hashiyama, Tomiki;Otsuka, Hisao;Watanabe, Akishige;Gaino, Mitsunori;Takahashi, Kaoru;Date, Tadamasa;Okamura, Kimio;Takeda, Mikio;Narita, Hiroshi;Murata, Sakae;Odawara, Akio;Sasaki, Haruhiko;Nagao, Taku. And the article was included in Chemical & Pharmaceutical Bulletin in 1997.Quality Control of 5,6-Dimethoxybenzo[d]thiazol-2-amine This article mentions the following:
2,3-Dihydro-1,5-benzothiazepin-4(5H)-ones,e.g., I (R1 = 6-, 7-, 8-Me, 7-CF3, 7-OMe, etc., R2 = OMe, OCF3, Me, etc.), substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1,5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation-inhibitory activities were investigated. (-)-Cis-3-Acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-8-methyl-2-(4-m ethylphenyl)-1,5-benzothiazepin-4(5H)-one was selected for further studies as a potent inhibitor of platelet aggregation. In the experiment, the researchers used many compounds, for example, 5,6-Dimethoxybenzo[d]thiazol-2-amine (cas: 6294-52-6Quality Control of 5,6-Dimethoxybenzo[d]thiazol-2-amine).
5,6-Dimethoxybenzo[d]thiazol-2-amine (cas: 6294-52-6) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Quality Control of 5,6-Dimethoxybenzo[d]thiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica