Radical reactivity in thiazoles. III. Synthesis of aryl thiazoles and their derivatives. An analytical study was written by Varnin, G.;Aune, J. P.;Dou, H. J. M.;Metzger, J.. And the article was included in Bulletin de la Societe Chimique de France in 1967.Name: 5-Phenylthiazole This article mentions the following:
Aryl- and arylalkylthiazoles were prepared and their uv, ir, and N.M.R. spectra determined Thus, according to the method of Gabriel, thioamides were prepared by treating 0.1 mole of an amide in dioxane with 1.5/5 mole P2S5 45 min. at 40°. Formation of the resultant thioamides was followed by thin layer chromatog. using silica GF-254 and C6H6 containing 5% EtOH. The obtained thioamide was treated with 0.1 mole of the carbonyl derivative at 60°, and the reaction mixture kept 2 hrs. at 100° and acidified, and dioxane was steam distilled The resulting reaction product was neutralized and steam distilled to give the corresponding thiazole. Higher yields of thiazoles were obtained by using absolute EtOH in the presence of fused NaOAc and drops of piperidine. The α-bromoketones were prepared by treating the corresponding ketones with Br2 at 50-5° in aqueous solution in the presence of KClO4 as described by Catch and D. F. Elliot. Bromination may be also carried by the use of NaOBr, or N-bromosuccinimide. The thiazoles (I) prepared are listed in the table. The prepared thiazoles were analyzed by gas chromatog. using 10% silicone SE 30 on 60/80 mesh fire brick. The retention volume for I were given at 200° and were compared with those obtained on 5% carbowax 20 M on chromosorb P 60/80 mesh. [TABLE OMITTED] The Rf and Rm values for I were given using silica DF-5 and (1:1) C6H6-CH2Cl2 eluant mixture or Al2O3 DF-5 and 55:15 heptane-CH2Cl2 eluant mixture thin layer chromatog. The conditions were given. The uv, ir, and N.M.R. spectra were discussed. 65 references. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Name: 5-Phenylthiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Name: 5-Phenylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica