Indolyl and dihydroindolyl N-glycinamides as potent and in vivo active NPY5 antagonists was written by Wu, Lingyun;Lu, Kai;Packiarajan, Mathivanan;Jubian, Vrej;Chandrasena, Gamini;Wolinsky, Toni C.;Walker, Mary W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Formula: C7H4ClNOS This article mentions the following:
A novel series of indolyl and dihydroindolyl glycinamides were identified as potent NPY5 antagonists with in vivo activity from screen hit I. The dihydroindolyl glycinamide II significantly inhibits NPY5 agonist induced feeding at a dose of 0.1 mg/kg. The indolyl glycinamide III also inhibits NPY5 agonist induced feeding at a dose of 1 mg/kg. Both II and III represent potential tools for further investigation into the biol. of the NPY5 receptor. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3Formula: C7H4ClNOS).
6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Formula: C7H4ClNOS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica