The human health implications of antibiotic resistance in environmental isolates from two nebraska watersheds was written by Donner, Linsey;Staley, Zachery R.;Petali, Jonathan;Sangster, Jodi;Li, Xu;Mathews, Wayne;Snow, Daniel;Howe, Adina;Soupir, Michelle;Bartelt-Hunt, Shannon. And the article was included in Microbiology Spectrum in 2022.Recommanded Product: 4-Amino-N-(thiazol-2-yl)benzenesulfonamide This article mentions the following:
One Health field-based approaches are needed to connect the occurrence of antibiotics present in the environment with the presence of antibiotic resistance genes (ARGs) in Gram-neg. bacteria that confer resistance to antibiotics important in for both veterinary and human health. Water samples from two Nebraska watersheds influenced by wastewater effluent and agricultural runoff were tested for the presence of antibiotics used in veterinary and human medicine. The water samples were also cultured to identify the bacteria present. Of those bacteria isolated, the Gram-neg. rods capable of causing human infections had antimicrobial susceptibility testing and whole-genome sequencing (WGS) performed to identify ARGs present. Of the 211 bacterial isolates identified, 37 belonged to pathogenic genera known to cause human infections. Genes conferring resistance to beta-lactams, aminoglycosides, fosfomycins, and quinolones were the most frequently detected ARGs associated with horizontal gene transfer (HGT) in the watersheds. WGS also suggest recent HGT events involving ARGs transferred between watershed isolates and bacteria of human and animal origins. The results of this study demonstrate the linkage of antibiotics and bacterial ARGs present in the environment with potential human and/or veterinary health impacts. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(thiazol-2-yl)benzenesulfonamide (cas: 72-14-0Recommanded Product: 4-Amino-N-(thiazol-2-yl)benzenesulfonamide).
4-Amino-N-(thiazol-2-yl)benzenesulfonamide (cas: 72-14-0) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 4-Amino-N-(thiazol-2-yl)benzenesulfonamide
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica