Catalyst and additive-free regioselective oxidative C-H thio/selenocyanation of arenes and heteroarenes with elemental sulfur/selenium and TMSCN was written by Feng, Chengtao;Peng, Ya;Ding, Guangrong;Li, Xiangxiao;Cui, Chang;Yan, Yizhe. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Recommanded Product: 15864-32-1 This article mentions the following:
A regioselective oxidative C-H thio/selenocyanation of arenes and heteroarenes with TMSCN and elemental sulfur/selenium was demonstrated under catalyst-free and additive-free conditions. DMSO (DMSO) was employed as the mild oxidant as well as the solvent. The reaction was operationally simple and scalable with a broad substrate scope. Compared to previous reports, this protocol was distinguished by avoiding the use of any catalyst or additive, the novel SCN/SeCN source, the different reaction mechanism and gram-scale synthesis. In the experiment, the researchers used many compounds, for example, 2-Amino-6-bromobenzothiazole (cas: 15864-32-1Recommanded Product: 15864-32-1).
2-Amino-6-bromobenzothiazole (cas: 15864-32-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Recommanded Product: 15864-32-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica