Facile Synthesis of Amides through Transamidation with Iodine under Neat Conditions was written by Girase, Pankaj S.;Kumar, Vishal;Dhawan, Sanjeev;Karpoormath, Rajshekhar. And the article was included in ChemistrySelect in 2022.Application of 104-96-1 This article mentions the following:
Iodine and NH2OH.HCl mediated transamidation of unactivated amides with a variety of amines under thermal/microwave irradiations was reported. The current strategy was effective for a wide variety of primary, secondary and tertiary amides and allows formylation, acylation and benzoylation of various amines. The primary advantages of the current protocol were simple, rapid, absence of metal catalyst, low-cost starting material as a solvent, and low environmental impact during the synthesis process. In the experiment, the researchers used many compounds, for example, 4-(Methylthio)aniline (cas: 104-96-1Application of 104-96-1).
4-(Methylthio)aniline (cas: 104-96-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 104-96-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica