Microwave-assisted solid-phase synthesis of cephalosporin derivatives with antibacterial activity was written by Kidwai, Mazaahir;Misra, Preeti;Bhushan, Kumar R.;Saxena, Rajendra K.;Singh, Meena. And the article was included in Monatshefte fuer Chemie in 2000.Name: 2-(Benzo[d]thiazol-2-ylthio)acetic acid This article mentions the following:
The reaction of heterocyclic acids with 7-amino-cephalosporanic acid adsorbed on basic alumina under microwave irradiation afforded the N-acylated cephalosporin analogs in satisfactory yield. All compounds were tested for their antibacterial activity; some of them showed significant antibacterial properties. Cefotaxime and cephalothin were used as reference drugs. In the experiment, the researchers used many compounds, for example, 2-(Benzo[d]thiazol-2-ylthio)acetic acid (cas: 6295-57-4Name: 2-(Benzo[d]thiazol-2-ylthio)acetic acid).
2-(Benzo[d]thiazol-2-ylthio)acetic acid (cas: 6295-57-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Name: 2-(Benzo[d]thiazol-2-ylthio)acetic acid
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica