Synthesis and Antimicrobial Activity of Aurone Derivatives Containing Heterocyclic Substituents was written by Li, Yi;Zhao, Haiqing;Niu, Chao;Aisa, Haji Akber;Hou, Xueling. And the article was included in Russian Journal of General Chemistry in 2022.Product Details of 3364-80-5 This article mentions the following:
A series of aurone compounds with the B ring substituted by different heterocycles has been synthesized. All synthesized compounds have been tested for antibacterial activity. It has been determined that different heterocyclic substituents modulate the antibacterial spectrum of aurones. Indole-substituted aurones display good inhibitory activity against Gram-pos. bacteria. Thiophene-substituted aurones exhibit inhibitory activity against fungi. Aminopyrimidine-substituted aurones exhibit promising inhibitory activity against Gram-neg. bacteria. Authors have determined that 2-arylimidazo[1,2-a]pyridones I (R1 = H, OMe) can be used as a platform for antifungal agents design. In the experiment, the researchers used many compounds, for example, Thiazole-4-carbaldehyde (cas: 3364-80-5Product Details of 3364-80-5).
Thiazole-4-carbaldehyde (cas: 3364-80-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Product Details of 3364-80-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica