Synthesis of the (benzothiazolylthio)carboxylic acids by use of ultrasound irradiation in phase transfer catalysis medium was written by Li, Yingjun;Li, Lina;Sun, Shuqin;Hu, Zhijun;Song, Yongbo. And the article was included in Hebei Shifan Daxue Xuebao, Ziran Kexueban in 2011.Synthetic Route of C9H7NO2S2 This article mentions the following:
(Benzothiazolylthio)carboxylic acids, (2-benzothiazolylthio)acetic acid and 3-(2-benzothiazolylthio)propionic acid were synthesized by the technique of ultrasonic irradiation and phase transfer catalysis. Their structures were confirmed by IR, 1HNMR and 13CNMR. The influences of the reaction temperature, the reaction time, the solvent, the catalyst and the ultrasonic irradiation on the reaction were investigated and optimum exptl. conditions were found. Compared with the literature methods, this synthetic method had such advantages as mild condition, simple operation, short reaction time, lower reaction temperature and higher yield. In the experiment, the researchers used many compounds, for example, 2-(Benzo[d]thiazol-2-ylthio)acetic acid (cas: 6295-57-4Synthetic Route of C9H7NO2S2).
2-(Benzo[d]thiazol-2-ylthio)acetic acid (cas: 6295-57-4) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Synthetic Route of C9H7NO2S2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica