Interactions of glucose 6-phosphate dehydrogenase deficiency with drug acetylation and hydroxylation reactions was written by Magon, Arlene M.;Leipzig, Rosanne M.;Zannoni, Vincent G.;Brewer, George J.. And the article was included in Journal of Laboratory and Clinical Medicine in 1981.HPLC of Formula: 127-76-4 This article mentions the following:
It is hypothesized that the bimodal distribution of hemolytic response by glucose 6-phosphate dehydrogenase (G6PD) [9001-40-5]-deficient individuals to particular drugs such as sulfones may be due to the genetically determined acetylation rate of those drugs. Since metabolism, e.g., hydroxylation, may be required for these drugs to become hemolytic, genetically and environmentally determined variation in hydroxylation of a drug may also contribute to this variability in hemolytic response. To test the possibilities that acetylation and hydroxylation alter the hemolytic potential of these drugs, G6PD-deficient and normal red cells were incubated with mouse liver microsomes at 2 states of hydroxylase activity (uninduced and induced), an NADPH-generating system, and acetylated or unacetylated drug. GSH depletion was then measured in the cells as an indicator of prelytic cell damage. In the presence of induced (high hydroxylase activity) microsomes, promizole [473-30-3] or DDS [80-08-0] in unacetylated form caused the highest level of GSH depletion in G6PD-deficient red cells. Acetylation protected against GSH depletion. The specificity of the hydroxylation reaction in producing marked GSH depletion was shown by the protective effect of a specific hydroxylation inhibitor. Thus, G6PD-deficient, genetically slow acetylators, having high microsomal activity, would be most susceptible to promizole- or DDS-induced hemolysis, compared to other metabolic phenotypes. In addition, the bimodality in hemolytic response to promizole probably corresponds to the bimodal distribution of acetylator phenotype in the population. In the experiment, the researchers used many compounds, for example, N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4HPLC of Formula: 127-76-4).
N-(4-(N-(Thiazol-2-yl)sulfamoyl)phenyl)acetamide (cas: 127-76-4) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.HPLC of Formula: 127-76-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica