Olawode, Emmanuel O. et al. published their research in ARKIVOC (Gainesville, FL, United States) in 2018 | CAS: 2103-99-3

4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 2103-99-3

Synthesis and biological screening of diethyl [N-(thiazol-2-yl)carbamoyl]methylphosphonates was written by Olawode, Emmanuel O.;Tandlich, Roman;Prinsloo, Earl;Isaacs, Michelle;Hoppe, Heinrich;Seldon, Ronnett;Warner, Digby F.;Steenkamp, Vanessa;Kaye, Perry T.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2018.Reference of 2103-99-3 This article mentions the following:

A three-step synthesis, involving condensation of bromomethyl aryl ketones with urea to afford 2- aminothiazoles, their chloroacetylation and subsequent solvent-free Arbuzov phosphonation has afforded a series of novel di-Et [N-(thiazol-2-yl)carbamoyl]methylphosphonates 3a3f in good overall yields; the 4- carboxythiazole analog 3g was obtained by selective hydrolysis of the corresponding Et ester 3f. The phosphonate esters exhibited significant anti-cancer activity (nM – low 渭M IC50 values) against SH-SY5Y cells and, in one case, 7.6渭M MIC90 anti-TB activity against the virulent M. tuberculosis H37Rv strain; the chloroacetamido precursors all exhibited some antimalarial (PfLDH) activity, three with IC50 values in the range 1.0 – 8.9渭螠. In the experiment, the researchers used many compounds, for example, 4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3Reference of 2103-99-3).

4-(4-Chlorophenyl)thiazol-2-amine (cas: 2103-99-3) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1).Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Reference of 2103-99-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Min et al. published their research in Bioorganic & Medicinal Chemistry in 2006 | CAS: 20358-07-0

2-Amino-5-fluorobenzothiazole (cas: 20358-07-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: 2-Amino-5-fluorobenzothiazole

Synthesis of carbon-11 labeled fluorinated 2-arylbenzothiazoles as novel potential PET cancer imaging agents was written by Wang, Min;Gao, Mingzhang;Mock, Bruce H.;Miller, Kathy D.;Sledge, George W.;Hutchins, Gary D.;Zheng, Qi-Huang. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Recommanded Product: 2-Amino-5-fluorobenzothiazole This article mentions the following:

Fluorinated 2-arylbenzothiazoles are new potential antitumor drugs, which show potent and selective inhibitory activity against breast, lung, and colon cancer cell lines. Carbon-11 labeled fluorinated 2-arylbenzothiazoles may serve as novel probes for positron emission tomog. (PET) to image tyrosine kinase in cancers. The preparation of 4-fluorinated 2-arylbenzothiazoles 4-fluoro-2-(3-benzloxy-4-methoxyphenyl)benzothiazole (6a) and 4-fluoro-2-(3,4-dimethoxyphenyl)benzothiazole (6b) was achieved by a modification of Jacobson thioanilide radical cyclization chem. Hydrogenolytic cleavage of the benzyl ether group of compound 6a using H2/Pd-C provided the precursor 4-fluoro-2-(3-hydroxy-4-methoxyphenyl)benzothiazole (7) for radiolabeling. Synthesis of radiolabeling precursors and the reference standards 5- and 6-fluorinated arylbenzothiazoles (11c-n) was achieved via the reaction of o-aminothiophenol disulfides with substituted benzaldehydes under reducing conditions. The target radiotracers carbon-11 labeled 4-, 5-, and 6-fluorinated arylbenzothiazoles were prepared by O-[11C]methylation of the phenolic hydroxyl precursors with [11C]methyl triflate and isolated by solid-phase extraction (SPE) purification in 30-55% radiochem. yields. In the experiment, the researchers used many compounds, for example, 2-Amino-5-fluorobenzothiazole (cas: 20358-07-0Recommanded Product: 2-Amino-5-fluorobenzothiazole).

2-Amino-5-fluorobenzothiazole (cas: 20358-07-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: 2-Amino-5-fluorobenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lempiainen, Harri et al. published their research in Molecular Endocrinology in 2005 | CAS: 338404-52-7

6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime (cas: 338404-52-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C19H12Cl3N3OS

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein was written by Lempiainen, Harri;Molnar, Ferdinand;Gonzalez, Manuel Macias;Perakyla, Mikael;Carlberg, Carsten. And the article was included in Molecular Endocrinology in 2005.Electric Literature of C19H12Cl3N3OS This article mentions the following:

Ligand-dependent signal transduction by nuclear receptors (NRs) includes dynamic exchanges of coactivator (CoA) and corepressor (CoR) proteins. Here the authors focused on the structural determinants of the antagonist- and inverse agonist-enhanced interaction of the endocrine NR vitamin D receptor (VDR) and the adopted orphan NR constitutive androstane receptor (CAR) from two species with the CoR NR corepressor. The authors found that the pure VDR antagonist ZK168281 and the human CAR inverse agonist clotrimazole are both effective inhibitors of the CoA interaction of their resp. receptors, whereas ZK168281 resembled more the mouse CAR inverse agonist androstanol in its ability to recruit CoR proteins. Mol. dynamics simulations resulted in comparable models for the CoR receptor interaction domain peptide bound to VDR/antagonist or CAR/inverse agonist complexes. A salt bridge between the CoR and a conserved lysine in helix 4 of the NR is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus. The comparable mol. mechanisms that explain the similar functional profile of antagonist and inverse agonists are likely to be extended from VDR and CAR to other members of the NR superfamily and may lead to the design of even more effective ligands. In the experiment, the researchers used many compounds, for example, 6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime (cas: 338404-52-7Electric Literature of C19H12Cl3N3OS).

6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime (cas: 338404-52-7) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 掳C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C19H12Cl3N3OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pentimalli, Luciano et al. published their research in Annali di Chimica (Rome, Italy) in 1989 | CAS: 40172-65-4

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Condensation of aromatic amines with nitrosobenzene in basic medium. II. Heteroaromatic amines was written by Pentimalli, Luciano;Milani, Giovanni. And the article was included in Annali di Chimica (Rome, Italy) in 1989.Category: thiazole This article mentions the following:

Aminobenzothiazoles, -naphthothiazoles and -1,2,4-thiadiazoles condense, in alk. medium, with nitrosobenzene as well as its 4-chloro derivative to give the corresponding azo compounds Aminothiazoles and -1,3,4-thiadiazoles did not give condensation products. 4-Nitro- and 4-dimethylaminonitrosobenzene gave the corresponding azoxybenzene as main reaction product. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Category: thiazole).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mal’tseva, V. P. et al. published their research in Zashchita Metallov in 1979 | CAS: 40172-65-4

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine

Correlation between the inhibiting action of 2-aminothiazoles and their electron structure was written by Mal’tseva, V. P.;Momsenko, A. P.. And the article was included in Zashchita Metallov in 1979.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine This article mentions the following:

Quantum chem. calculations were made for electron structure of 2-aminobenzothiazole [136-95-8] (I), 2-aminonaphtho-1,2,4,5-thiazole [40172-65-4] (II), and 2-amino-4,5,6,7-tetrahydrobenzothiazole [2933-29-1] (III). Their corrosion inhibition and polarization voltage were determined in 1N HCl and 1N H2SO4 for steel St2 [12742-82-4] and St 3 [39296-41-8]. Corrosion rate reductions were 85-87, 90.4-93.5, and 96-99.5% for I, II, and III, resp. The mols. showed effective charge separation on N and S. In the experiment, the researchers used many compounds, for example, Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine).

Naphtho[1,2-d]thiazol-2-amine (cas: 40172-65-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Application In Synthesis of Naphtho[1,2-d]thiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bitter, Istvan et al. published their research in Heterocycles in 1987 | CAS: 2346-00-1

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C4H7NS

Nitrogen bridgehead compounds. Part 67. Preparation of novel polycyclic quaternary salts was written by Bitter, Istvan;Pete, Bela;Agai, Bela;Toke, Laszlo;Toth, Gabor;Hermecz, Istvan;Simon, Kalman;Meszaros, Zoltan;Parkanyi, Laszlo. And the article was included in Heterocycles in 1987.Computed Properties of C4H7NS This article mentions the following:

The cycloaddition reaction of (aminochloromethylene)pyridopyrimidines I (R1 = CO2Et, cyano) with 3,4-dihydroisoquinolines gave ioquinodiazaazoniaphenalene salts II (R2 = H, Me; R3 = H, OMe; X = Cl, ClO4). Similarly fused compounds were obtained from 2-thiazoline and 2-oxazoline derivatives, benzothiazole, and a benzoxazole derivative The crystal and mol. structure of II (R1 = cyano, R2 = R3 = H, X = Cl) were obtained. In the experiment, the researchers used many compounds, for example, 2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1Computed Properties of C4H7NS).

2-Methyl-4,5-dihydrothiazole (cas: 2346-00-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C4H7NS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zamiri, Maryam et al. published their research in ACS Medicinal Chemistry Letters in 2021 | CAS: 15864-32-1

2-Amino-6-bromobenzothiazole (cas: 15864-32-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Related Products of 15864-32-1

2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing was written by Zamiri, Maryam;Cheung, Peter K.;Brockman, Mark A.;Brumme, Zabrina L.;Chabot, Benoit;Cochrane, Alan;Grierson, David S.. And the article was included in ACS Medicinal Chemistry Letters in 2021.Related Products of 15864-32-1 This article mentions the following:

The observation that stilbene 3 (5350150) blocks HIV replication through its impact on HIV mRNA processing prompted a program to develop non-cytotoxic analogs that maintain its mechanism of action. This initially involved replacement of the central double bond in 3 by an amide function and the quinoline motif by a 2-aminobenzothiazole subunit, as in 12jj (R’ = Cl), 12pp (R = NO2), and 12vv (R = CF3). On the basis of the possible CF3 鈫?NO2 bioisostere relationship in 12vv and 12pp, compound 23 was prepared and also found to be active. In the final step, the thiazole compounds 28 (GPS488) (EC50 = 1.66渭M) and 29 (GPS491) (EC50 = 0.47渭M) were prepared and evaluated. Similar activity and cell viability values (therapeutic index (TI = CC50/EC50) values of 50-100) were observed in primary peripheral blood mononuclear cells. Furthermore, they remained active against a panel of HIV mutant strains displaying resistance to individual drugs used in antiretroviral therapy. It was determined that compound 29 suppressed expression of the HIV-1 structural protein Gag and altered HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins, a pattern similar to that seen for compound 3. In the experiment, the researchers used many compounds, for example, 2-Amino-6-bromobenzothiazole (cas: 15864-32-1Related Products of 15864-32-1).

2-Amino-6-bromobenzothiazole (cas: 15864-32-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, 蟺-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Related Products of 15864-32-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wada, Naohisa et al. published their research in Digestive diseases (Basel, Switzerland) in 2021 | CAS: 1110766-97-6

(S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (cas: 1110766-97-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Reference of 1110766-97-6

Impact of Anti-GPIIb/IIIa Antibody-Producing B Cells as a Predictor of the Response to Lusutrombopag in Thrombocytopenic Patients with Liver Disease. was written by Wada, Naohisa;Uojima, Haruki;Satoh, Takashi;Okina, Sosei;Iwasaki, Shuichiro;Shao, Xue;Takiguchi, Hayato;Arase, Yoshitaka;Itokawa, Norio;Atsukawa, Masanori;Miyazaki, Koji;Hidaka, Hisashi;Kako, Makoto;Kagawa, Tatehiro;Iwakiri, Katsuhiko;Horie, Ryouichi;Suzuki, Takahiro;Koizumi, Wasaburo. And the article was included in Digestive diseases (Basel, Switzerland) in 2021.Reference of 1110766-97-6 This article mentions the following:

BACKGROUND: To make an accurate estimate of the response to thrombopoietin (TPO) receptor agonists for thrombocytopenia associated with chronic liver disease, we evaluated the influence of antiplatelet autoantibodies on the response to lusutrombopag in thrombocytopenic patients with liver disease. METHODS: A prospective study was conducted at 2 hospitals. Thrombocytopenic patients with liver disease received oral lusutrombopag 3.0 mg once daily for up to 7 days. We analyzed changes in platelet counts from baseline to the maximum platelet count on days 9-14. The definition of clinical response was a platelet count of 鈮? 脳 104/渭L with an increased platelet count of 鈮? 脳 104/渭L from baseline. We assessed the correlation between the response to treatment drug and antiplatelet autoantibodies measured by anti-GPIIb/IIIa antibody-producing B cells. RESULTS: Thirty patients received the trial drug. There were 25 responders and 5 nonresponders. The median change in platelet counts was 3.9 脳 104/渭L (95% CI 2.8-4.6, p < 0.0001). The correlation between change in platelet counts and the frequency of the anti-glycoprotein IIb/IIIa antibody-producing B cells was moderate (r = 0.414, 95% CI 0.064-0.674, p = 0.023). In multivariate analysis of factors affecting the change in platelet counts, the anti-GPIIb/IIIa antibody-producing B cells were identified as an independent factor (regression coefficient [B] = 0.089; CI 0.021-0.157, p = 0.013). CONCLUSION: Anti-GPIIb/IIIa antibody-producing B cells may be a predictor for TPO receptor agonists in patients with chronic liver disease. In the experiment, the researchers used many compounds, for example, (S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (cas: 1110766-97-6Reference of 1110766-97-6).

(S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid (cas: 1110766-97-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Reference of 1110766-97-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Li et al. published their research in Organic Letters in 2015 | CAS: 950194-37-3

(S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C15H12N2S

Diastereoselective and Enantioselective Silylation of 2-Arylcyclohexanols was written by Wang, Li;Akhani, Ravish K.;Wiskur, Sheryl L.. And the article was included in Organic Letters in 2015.Synthetic Route of C15H12N2S This article mentions the following:

The silylation-based kinetic resolution of trans 2-arylcyclohexanols was accomplished by employing a triaryl silyl chloride as the derivatizing reagent with a com. available isothiourea catalyst. The methodol. is selective for the trans diastereomer over the cis, which provides an opportunity to selectively derivatize one stereoisomer out of a mixture of four. By employing this technol., a facile, convenient method to form a highly enantiomerically enriched silylated alc. was accomplished through a 1-pot reduction-silylation sequence that started with a 2-aryl-substituted ketone. In the experiment, the researchers used many compounds, for example, (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3Synthetic Route of C15H12N2S).

(S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Blokh, G. A. et al. published their research in Khimicheskaya Tekhnologiya (Kiev) in 1983 | CAS: 6846-35-1

5-Amino-3H-1,2,4-dithiazole-3-thione (cas: 6846-35-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of 5-Amino-3H-1,2,4-dithiazole-3-thione

Vulcanization of butadiene-nitrile rubber in the presence of ammonium thiocyanate was written by Blokh, G. A.;Zorina, V. B.;Duplyakin, V. D.. And the article was included in Khimicheskaya Tekhnologiya (Kiev) in 1983.Safety of 5-Amino-3H-1,2,4-dithiazole-3-thione This article mentions the following:

Regression equations were derived for optimizing the vulcanization of SKN-26 rubber in the presence of NH4SCN (I)-Altax (II) [120-78-5]-ZnO system or Ixanthanehydride (III) [6846-35-1] system at 416 K with respect to 300% modulus, tensile strength, and breaking elongation. The optimum content of I, II, ZnO, and III were determined from solutions of the equations. In the experiment, the researchers used many compounds, for example, 5-Amino-3H-1,2,4-dithiazole-3-thione (cas: 6846-35-1Safety of 5-Amino-3H-1,2,4-dithiazole-3-thione).

5-Amino-3H-1,2,4-dithiazole-3-thione (cas: 6846-35-1) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of 5-Amino-3H-1,2,4-dithiazole-3-thione

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica