Enantioselective α-Benzylation of Acyclic Esters Using π-Extended Electrophiles was written by Schwarz, Kevin J.;Yang, Chao;Fyfe, James W. B.;Snaddon, Thomas N.. And the article was included in Angewandte Chemie, International Edition in 2018.Safety of (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole This article mentions the following:
The first asym. cooperative Lewis base/palladium catalyzed benzylic alkylation of acyclic esters is reported. This reaction proceeds via stereodefined C1-ammonium enolate nucleophiles. Critical to its success was the identification of benzylic phosphate electrophiles, which were uniquely reactive. Alkylated products were obtained with very high levels of enantioselectivity, and this method has been applied toward the synthesis of the thrombin inhibitor DX-9065a. In the experiment, the researchers used many compounds, for example, (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3Safety of (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole).
(S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Safety of (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica