Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity was written by Smith, Nicholas D.;Poon, Steve F.;Huang, Dehua;Green, Mitchell;King, Christopher;Tehrani, Lida;Roppe, Jeffrey R.;Chung, Janice;Chapman, Deborah P.;Cramer, Merryl;Cosford, Nicholas D. P.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Recommanded Product: 3364-80-5 This article mentions the following:
Structure-activity relationship studies focused on bio-isosteric replacements of 2-pyridyl resulted in mGlu5 receptor antagonists with reduced inhibition of cytochrome P 450 1A2. This led to highly potent, selective and orally bioavailable 2-imidazolyl tetrazoles such as I that are devoid of cytochrome P 450 inhibitory activity. In the experiment, the researchers used many compounds, for example, Thiazole-4-carbaldehyde (cas: 3364-80-5Recommanded Product: 3364-80-5).
Thiazole-4-carbaldehyde (cas: 3364-80-5) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 3364-80-5
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica