Thiazolylalkylamines: synthesis of congeners of imidazolylethylamines and their effects on gastric secretion was written by Vitali, T.;Impicciatore, M.;Plazzi, P. V.;Bordi, F.;Morini, G.. And the article was included in Farmaco, Edizione Scientifica in 1986.Electric Literature of C5H8N2OS This article mentions the following:
Eight 2-aminothiazolylethylamines (I, R = NH2, NHMe, or NMe2; R1 and R2 = H, Me; X = Y = N, S), as well as 4 related compounds unsaturated in the ring or side chain, were prepared by 3 different reaction sequences, for which the mechanisms are illustrated. Since these compounds contain the S-aminoalkylisothiourea group which, in other instances stimulates gastric secretion, they were tested for histaminic-H2 agonist activity in vitro (isolated guinea pig fundus) and in vivo (gastric acid secretion in the cat) and for some other activities. Examination of structure-activity relations excluded the possibility that the juxtanuclear NH2 group of the compounds interacts with the H2 receptor; the 2-aminothiazole moiety is not pharmacol. equivalent to the 2-aminoimidazole or isothiourea groups. This strengthens the hypothesis that the flexibility of the mol. is a fundamental requirement for the H2-stimulant properties of S-(3-dimethylaminopropyl)isothiourea and that the different behavior of 2-aminohistamine relative to 2-methylhistamine is due to the existence of a hydrophilic area in the histaminic-H2 receptor which is capable of accepting the juxtanuclear NH2 group of the former. In the experiment, the researchers used many compounds, for example, 2-Amino-5-(2-hydroxyethyl)thiazole (cas: 105773-93-1Electric Literature of C5H8N2OS).
2-Amino-5-(2-hydroxyethyl)thiazole (cas: 105773-93-1) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Electric Literature of C5H8N2OS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica