Bulky Yet Flexible Pd-PEPPSI-IPentAn for the Synthesis of Sterically Hindered Biaryls in Air was written by Lu, Dong-Dong;He, Xu-Xian;Liu, Feng-Shou. And the article was included in Journal of Organic Chemistry in 2017.Recommanded Product: 615-20-3 This article mentions the following:
In this report, a type of moisture and air stable Pd-PEPPSI-IPentAn complex with the combination of acenaphthyl on the backbone and isopentyl groups on N-aryl moieties, I, was described and applied in the Suzuki-Miyaura cross-coupling reaction in air. The reaction conditions were optimized, and the structure-reactivity relationships between I and other classical efficient Pd-PEPPSI complexes were investigated intensively. Our study demonstrated that both the backbone and N-aryl moieties gave rise to a significant effect on this transformation when exposed to air. A wide range of sterically hindered (hetero)aryl chlorides with (hetero)arylboronic acids were compatible, giving good to excellent isolated yields of sterically hindered bi(hetero)aryls. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzothiazole (cas: 615-20-3Recommanded Product: 615-20-3).
2-Chlorobenzothiazole (cas: 615-20-3) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 615-20-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica