One pot synthesis using supported reagents system KSCN/SiO2-RNH3OAc/Al2O3: synthesis of 2-aminothiazoles and N-allylthioureas was written by Aoyama, Tadashi;Murata, Sumiko;Arai, Izumi;Araki, Natsumi;Takido, Toshio;Suzuki, Yoshitada;Kodomari, Mitsuo. And the article was included in Tetrahedron in 2006.Quality Control of 4,5-Diphenylthiazol-2-amine This article mentions the following:
A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from com. available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH3OAc/Al2O3, in which α-halo ketones react first with KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final products, 2-aminothiazoles, in good yield. Allyl bromides react with KSCN/SiO2 and the products, allyl isothiocyanates, react with RNH3OAc/Al2O3 to give N-allylthioureas. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Quality Control of 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Quality Control of 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica