Benzothiazole-based compounds as potent endothelial lipase inhibitors was written by Meng, Wei;Adam, Leonard P.;Behnia, Kamelia;Zhao, Lei;Yang, Richard;Kopcho, Lisa M.;Locke, Gregory A.;Taylor, David S.;Yin, Xiaohong;Wexler, Ruth R.;Finlay, Heather. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.SDS of cas: 80945-86-4 This article mentions the following:
A series of benzothiazoles with a cyano group was synthesized and evaluated as endothelial lipase (EL) inhibitors for the potential treatment of cardiovascular diseases. Efforts to reduce mol. weight and polarity in the series led to improved physicochem. properties of these compounds, as well as selectivity for EL over hepatic lipase (HL). As a benchmark compound, I demonstrated potent EL activity, an acceptable absorption, distribution, metabolism and elimination (ADME) profile and pharmacokinetic (PK) exposure which allowed further evaluation in preclin. animal efficacy studies. In the experiment, the researchers used many compounds, for example, 6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4SDS of cas: 80945-86-4).
6-Bromo-2-chlorobenzothiazole (cas: 80945-86-4) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.SDS of cas: 80945-86-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica