Synthesis of α-phosphoramidate containing benzothiazole group was written by Xu, Xue-li;Song, Wei;Gao, Wei-xia. And the article was included in Huaxue Shiji in 2014.SDS of cas: 68867-17-4 This article mentions the following:
This work is designed to use 3-nitro-4-thiosalicylic acid as the substrate, which was taken to cyclization, esterification, reduction, oxidation and the addition reactions, it was 6 steps in all. 14α-Phosphoramidates e. g., I, which contained benzothiazole groups were synthesized. And the products were confirmed by m.p., NMR, MS and IR. In the experiment, the researchers used many compounds, for example, Benzothiazole-5-carboxylic acid (cas: 68867-17-4SDS of cas: 68867-17-4).
Benzothiazole-5-carboxylic acid (cas: 68867-17-4) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.SDS of cas: 68867-17-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica