Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands was written by Jean, Mickael;Renault, Jacques;Levoin, Nicolas;Danvy, Denis;Calmels, Thierry;Berrebi-Bertrand, Isabelle;Robert, Philippe;Schwartz, J. C.;Lecomte, J. M.;Uriac, Philippe;Capet, Marc. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Formula: C9H6ClNS This article mentions the following:
Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds Enhanced bioavailability and preferential brain distribution make (piperazinyl)butanamine derivative I a good candidate for pharmacol. and clin. evaluation. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-phenylthiazole (cas: 329794-40-3Formula: C9H6ClNS).
2-Chloro-5-phenylthiazole (cas: 329794-40-3) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Formula: C9H6ClNS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica