Marsden, David M. et al. published their research in Organic & Biomolecular Chemistry in 2010 | CAS: 55661-33-1

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Safety of Thiazol-2-ylmethanamine

Discovery of a quorum sensing modulator pharmacophore by 3D small-molecule microarray screening was written by Marsden, David M.;Nicholson, Rebecca L.;Skindersoe, Mette E.;Galloway, Warren R. J. D.;Sore, Hannah F.;Givskov, Michael;Salmond, George P. C.;Ladlow, Mark;Welch, Martin;Spring, David R.. And the article was included in Organic & Biomolecular Chemistry in 2010.Safety of Thiazol-2-ylmethanamine This article mentions the following:

The screening of large arrays of drug-like small-mols. was traditionally a time consuming and resource intensive task. New methodol. developed within the authors’ laboratories provides an attractive low cost, 3D microarray-assisted screening platform that could be used to rapidly assay thousands of compounds As a proof-of-principle the platform was exploited to screen a number of quorum sensing analogs. Quorum sensing was used by bacterium to initiate and spread infection; in this context its modulation may have significant clin. value. 3D microarray slides were probed with fluorescently labeled ligand-binding domains of the LuxR homolog CarR from Erwinia carotovora subsp. carotovora. The 3D microarray platform was used to discover the biol. active chloro-pyridine pharmacophore, which was validated using a fluorometric ligand binding assay and ITC. Analogs containing the chloro-pyridine pharmacophore are potent inhibitors of N-acyl-homoserine-lactone (AHL) mediated quorum sensing phenotypes in Serratia (IC50 ≃5 μM) and Pseudomonas aeruginosa (IC50 = 10-20 μM). In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Safety of Thiazol-2-ylmethanamine).

Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The nitrogen in thiazole is sp2 hybridized and the lone pair of electrons localized on the nitrogen is less reactive due to increased aromatic character and decreased basicity. It is protonated and alkylated/acylated at nitrogen forming hydrochloride and quaternary thiazolium salt.Safety of Thiazol-2-ylmethanamine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica