Konno, Sho et al. published their research in Bioorganic & Medicinal Chemistry in 2013 | CAS: 1826-13-7

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Name: 5-Phenylthiazole

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety was written by Konno, Sho;Thanigaimalai, Pillaiyar;Yamamoto, Takehito;Nakada, Kiyohiko;Kakiuchi, Rie;Takayama, Kentaro;Yamazaki, Yuri;Yakushiji, Fumika;Akaji, Kenichi;Kiso, Yoshiaki;Kawasaki, Yuko;Chen, Shen-En;Freire, Ernesto;Hayashi, Yoshio. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Name: 5-Phenylthiazole This article mentions the following:

We describe here the design, synthesis and biol. evaluation of a series of mols. toward the development of novel peptidomimetic inhibitors of SARS-CoV 3CLpro. A docking study involving binding between the initial lead compound (I) and the SARS-CoV 3CLpro motivated the replacement of a thiazole with a benzothiazole unit as a warhead moiety at the P1′ site. This modification led to the identification of more potent derivatives, including (II) (R1 = R2 = H; R1 = OMe, R2 = H; R1 = H, R2 = OMe; R1 = NMe2, H2 = H; R1 = H, R2 = NMe2), with IC50 or Ki values in the submicromolar to nanomolar range. In particular, compounds II (R1 = R2 = H; R1 = H, R2 = NMe2) exhibited the most potent inhibitory activities, with Ki values of 4.1 and 3.1 nM, resp. The peptidomimetic compounds identified through this process are attractive leads for the development of potential therapeutic agents against SARS. The structural requirements of the peptidomimetics with potent inhibitory activities against SARS-CoV 3CLpro may be summarized as follows: (i) the presence of a benzothiazole warhead at the S1′-position; (ii) hydrogen bonding capabilities at the cyclic lactam of the S1-site; (iii) appropriate stereochem. and hydrophobic moiety size at the S2-site and (iv) a unique folding conformation assumed by the phenoxyacetyl moiety at the S4-site. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Name: 5-Phenylthiazole).

5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Name: 5-Phenylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica