Synthesis and antimitotic activity of 3- and 5-halo-substituted bis(2-aminophenyl) disulfides and corresponding N-alkyl derivatives was written by Mazzone, G.;Pappalardo, G.. And the article was included in Farmaco, Edizione Scientifica in 1977.Computed Properties of C7H4ClNOS This article mentions the following:
Benzothiazolones I (R = H, alkyl, CH2CO2Et; R1 or R2 = H, the other is Cl or F) were heated with NaOH to yield eleven resp. diphenyl disulfides II (R3 = H, alkyl, CH2CO2H). Antimitotic activity was found for II (R1 = H, R2 = Cl, R3 = Me) and II (R1 = H, R2 = F, R3 = Me). In the experiment, the researchers used many compounds, for example, 6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3Computed Properties of C7H4ClNOS).
6-Chlorobenzo[d]thiazol-2(3H)-one (cas: 62266-81-3) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C7H4ClNOS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica