Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors was written by Parkes, Kevin E. B.;Ermert, Philipp;Faessler, Juerg;Ives, Jane;Martin, Joseph A.;Merrett, John H.;Obrecht, Daniel;Williams, Glyn;Klumpp, Klaus. And the article was included in Journal of Medicinal Chemistry in 2003.Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride This article mentions the following:
Data from both our own and literature studies of the biochem. and inhibition of influenza virus endonuclease was combined with data on the mechanism of action and the likely active site mechanism to propose a pharmacophore. The pharmacophore was used to design a novel structural class of inhibitors, some of which were found to have activities similar to that of known influenza endonuclease inhibitors and were also antiviral in cell culture. In the experiment, the researchers used many compounds, for example, 2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride).
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (cas: 69812-29-9) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application In Synthesis of 2-Acetamido-4-methylthiazole-5-sulfonyl chloride
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica