Synthesis of thiazolylquinazolin-4(3H)-ones was written by Badr, M. Z. A.;El-Sherief, H. A. H.;El-Naggar, G. M.;Mahmoud, A. M.. And the article was included in Indian Journal of Chemistry in 1979.Application of 6318-74-7 This article mentions the following:
3-Thiazolylquinazol-4-ones I (R = Me, Ph; R1 = H, CO2Et; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, 4-BrC6H4, Me) were prepared by condensing 3,1-benzoxazin-4(H)-ones II with aminothiazoles III. Heating 2-aroylaminothiazoles IV in dry pyridine also give I. 2-Styrylquinazol-4-ones I (R = 4-O2NC6H4CH:CH, R1 = H, Ph, CO2Et, R2 = Ph, Me, 4-MeC6H4; R = 4-ClC6H4CH:CH, R1 = R2 = Ph) were prepared by condensing aromatic aldehydes with I (R = Me). I and IV showed bactericidal activity. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Application of 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Application of 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica