Non-peptidic small molecule inhibitors of XIAP was written by Park, Cheol-Min;Sun, Chaohong;Olejniczak, Edward T.;Wilson, Alan E.;Meadows, Robert P.;Betz, Stephen F.;Elmore, Steven W.;Fesik, Stephen W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Recommanded Product: 6318-74-7 This article mentions the following:
Non-peptidic small mol. SMAC mimetics were designed and synthesized that bind to the BIR3 domain of XIAP using structure-based design. Substituted five-membered heterocycles such as thiazoles and imidazoles were identified that serve as replacements for peptide fragments of the lead. An example compound thus prepared and evaluated was an N-(thiazolyl)-L-alaninamide derivative (I). In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Recommanded Product: 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica