Microwave assisted one pot synthesis of 2-alkyl amino benzimidazoles, 2-alkyl amino benzoxazoles and 2-alkyl amino benzthiazoles by using various carbodiimides was written by Rapolu, Thirupathi;Naveen, Polkam;Pavan Kumar, K. V. P.;Reddy Leleti, Krishnakanth;korapolu, Raghubabu. And the article was included in Results in Chemistry in 2022.Quality Control of N-Phenylbenzo[d]thiazol-2-amine This article mentions the following:
A library of bioisosteres namely 2-amino substituted benzimidazole, 2-amino substituted benzoxazole, 2-amino substituted benzthiazole derivatives were synthesized by an efficient ligand free, zinc catalyzed one-pot cascade microwave irradiation technique. The procedure started with coupling of various carbodiimides with appropriately substituted o-phenylendiamine, o-aminophenol and o-aminothiols to give the corresponding derivatives in excellent yields. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Quality Control of N-Phenylbenzo[d]thiazol-2-amine).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Quality Control of N-Phenylbenzo[d]thiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica