Relative reactivity of groups bonded to positions 2 and 5 of the thiazole ring was written by Bosco, Marcella;Forlani, Luciano;Todesco, Paolo E.;Troisi, Luigi. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1976.Computed Properties of C9H7NS This article mentions the following:
The substitution of halogen by MeO-, MeS- and PhS- ions and oxidation of phenylsulfinyl to phenylsulfonyl by PhC(O)OOH at positions 2 and 5 of the thiazole ring were studied quant. The ratio of the reactivities of the positions was moderate and the unusual nucleophilic halogen displacement for 5-halothiazoles together with the oxidation of the 5-sulfinyl groups indicated the slightly pos. character of C-5. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Computed Properties of C9H7NS).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Computed Properties of C9H7NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica