Thin-layer chromatography of thiazole derivatives was written by Vernin, Gaston;Metzger, Jacques. And the article was included in Chimie Analytique (Paris) in 1964.Electric Literature of C9H7NS This article mentions the following:
A series of thiazoles having Cl, SMe, OH, NH2, or SH in the 2-position and phenyl, p-tolyl, p-bromophenyl, p-chlorophenyl, p-methoxyphenyl, or p-nitrophenyl in the 4-position are separated by thin-layer chromatography on silica gel using heptane or benzene as the eluting solvent. Some 2, 4, 5-trisubstituted thiazoles were also tried. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Electric Literature of C9H7NS).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C9H7NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica