Potassium iodide and ammonium nitrate catalyzed aerobic oxidative cyclization of ketones with thioureas in ionic liquid: an access to 2-aminothiazoles was written by Zhao, Jinwu;Xu, Jingxiu;Chen, Jiaxi;He, Minghua;Wang, Xiaoqin. And the article was included in Tetrahedron in 2015.Formula: C15H12N2S This article mentions the following:
An efficient procedure for the synthesis of 2-aminothiazoles via KI/NH4NO3-catalyzed oxidative cyclization of ketones and thioureas using mol. oxygen as a green oxidant is reported. Different ketones and thioureas went through the transformation and gave corresponding 2-aminothiazole heterocycles in satisfactory yields. E.g., in presence of KI/NH4NO3, H2SO4, and mol. oxygen in [Bmim]OTf/H2O (4:1), oxidative cyclization of PhCOMe and H2NCSNH2 gave 95% 2-aminothiazole derivative (I). In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Formula: C15H12N2S).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Formula: C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica