Liu, Jingbao et al. published their research in European Journal of Medicinal Chemistry in 2012 | CAS: 6318-74-7

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C15H12N2S

Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors was written by Liu, Jingbao;Jiang, Faqin;Jin, Yan;Zhang, Yong;Liu, Jingjing;Liu, Wenlu;Fu, Lei. And the article was included in European Journal of Medicinal Chemistry in 2012.Computed Properties of C15H12N2S This article mentions the following:

Thirty-two substituted ethenesulfonic acid ester derivatives were designed, synthesized and evaluated for their inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and selectivity over T-Cell protein tyrosine phosphatase (TCPTP). A preliminary structure-activity relationship studies demonstrated that the substitution at the aromatic center and the length of linker between the hydrophobic tail and aromatic center markedly affected the inhibitory activity against PTP1B and the selectivity over TCPTP. Specifically, two compounds revealed excellent inhibitory activity to PTP1B with IC50 = 1.3 μM and 1.5 μM, resp. and marked 10-fold and 20-fold selectivity over TCPTP. Cytotoxicity data showed low cytotoxicity for COS-7 cell with IC50 values >100 μM for most synthesized chems. The title compounds thus formed included (1E)-2-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]ethenesulfonic acid Et ester (I) and related substances, such as isoxazole derivatives and thiazole derivatives The synthesis of the target compounds was achieved using 4-bromo-3-oxopentanoic acid Me ester, 4-bromo-3-oxobutanoic acid Me ester, benzamide and benzenecarbothioamide as simple starting materials. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Computed Properties of C15H12N2S).

4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Computed Properties of C15H12N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica