Oxidative coupling of formamides with β-dicarbonyl compounds and the synthesis of 2-aminobenzothiazole using Cu(II)-functionalized Fe3O4 nanoparticles was written by Azizi, Kobra;Karimi, Meghdad;Heydari, Akbar. And the article was included in Tetrahedron Letters in 2015.Application of 1843-21-6 This article mentions the following:
The Fe3O4@EDTA-Cu(II) nanoparticles catalyzed oxidative coupling of formamides with β-dicarbonyl compounds is developed using tert-Bu hydroperoxide as an oxidant. In general, the enol carbamates are synthesized in excellent yields (up to 92%) under the optimized reaction conditions. Fe3O4@EDTA-Cu(II) has the advantage of being magnetically recoverable. Also, we have established a highly efficient Fe3O4@EDTA-Cu(II)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates for the synthesis of 2-aminobenzothiazoles. In the experiment, the researchers used many compounds, for example, N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6Application of 1843-21-6).
N-Phenylbenzo[d]thiazol-2-amine (cas: 1843-21-6) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 1843-21-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica