Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: Thiazol-2-ylmethanamine
Matrix Metalloproteinase Inhibitors: A Structure Activity Study was written by Levy, Daniel E.;Lapierre, France;Liang, Weisheng;Ye, Wenqing;Lange, Christopher W.;Li, Xiaoyuan;Grobelny, Damian;Casabonne, Marie;Tyrrell, David;Holme, Kevin;Nadzan, Alex;Galardy, Richard E.. And the article was included in Journal of Medicinal Chemistry in 1998.Name: Thiazol-2-ylmethanamine This article mentions the following:
Modifications around the dipeptide-mimetic core of hydroxamic acid based matrix metalloproteinase inhibitors I [AA = L-Trp, D-Trp, L-Trp(Me), L-3-benzothienylalanine, L-1- and -2-naphthylalanine, L-3- and -8-quinolylalanine, L-4-phenylphenylalanine, L-Phe, L-3- and -4-pyridylalanine, L–tert-leucine, L-abrine; R6 = NHMe, NH(CH2)4Me, NHCH2CH2OH, NHCH2CH2NHCO2CH2Ph, cyclopropylamino, cyclopentylamino, (S)- and (R)-1-indanylamino, (1R,2S)- and (1S,2R)-2-hydroxy-1-indanylamino, (S)-NHCHMePh, NHCH2Ph, piperonylamino, 2-, 3-, and 4-pyridylmethylamino, 2-(4-pyridyl)ethylamino, NHCH2CH2C6H4OH-4, 2-furanylmethylamino, 2-thiazolylmethylamino, 2-benzimidazolylamino, 3-(1-imidazolyl)propylamino, 3-(4-morpholinyl)propylamino; R2 = H, OH; R3 = CH2CHMe2, Bu, n-hexyl, n-octyl, OCHMe2, O(CH2)4Me] were studied. These variations incorporated a variety of natural, unnatural, and synthetic amino acids in addition to modifications of the P1′ and P3′ substituents. The results of this study indicate the following structural requirements: (1) Two key hydrogen bonds must be present between the enzyme and potent substrates. (2) Potent inhibitors must possess potent zinc-binding functionalities. (3) The potential importance of the hydrophobic group at position R3 as illustrated by its ability to impart greater relative potency against stromelysin when larger hydrophobic groups are used. (4) Requirements surrounding the nature of the amino acid appear to be more restrictive for stromelysin than for neutrophil collagenase, 72 kDa gelatinase, and 92 kDa gelatinase. These requirements may involve planar fused-ring aryl systems and possibly hydrogen-bonding capabilities. In the experiment, the researchers used many compounds, for example, Thiazol-2-ylmethanamine (cas: 55661-33-1Name: Thiazol-2-ylmethanamine).
Thiazol-2-ylmethanamine (cas: 55661-33-1) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: Thiazol-2-ylmethanamine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica