Nitration of thiazoles and isothiazoles. Application to 2-benzyl- and 2-phenethylthiazoles and to their mono and dimethyl derivatives. Phenylthiazoles and -isothiazoles was written by Baule, Michel;Vivaldi, Robert;Poite, Jean C.;Dou, Henri J. M.;Vernin, Gaston;Metzger, Jacques. And the article was included in Bulletin de la Societe Chimique de France in 1971.Application In Synthesis of 5-Phenylthiazole This article mentions the following:
Nitration of a series of thiazoles and isothiazoles with concentrated HNO3-H2SO4 showed strong deactivation of the Ph group due to the effect of pos. pole of the thiazole or isothiazole ring, which behaved differently. The pos. pole oriented substitution meta and para in 2-benzylthiazoles and para in 2-phenethylthiazoles. The exptl. results and calculated theoretical electronic ds. were not in good agreement. In the experiment, the researchers used many compounds, for example, 5-Phenylthiazole (cas: 1826-13-7Application In Synthesis of 5-Phenylthiazole).
5-Phenylthiazole (cas: 1826-13-7) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Application In Synthesis of 5-Phenylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica