Sodium Hydroxide Catalyzed N-Alkylation of (Hetero) Aromatic Primary Amines and N1,C5-Dialkylation of 4-Phenyl-2-aminothiazoles with Benzyl Alcohols was written by Donthiri, Ramachandra Reddy;Pappula, Venkatanarayana;Chandra Mohan, Darapaneni;Gaywala, Hiren H.;Adimurthy, Subbarayappa. And the article was included in Journal of Organic Chemistry in 2013.Recommanded Product: 4,5-Diphenylthiazol-2-amine This article mentions the following:
In the presence of a catalytic amount of NaOH, the selective N-alkylation of various heteroaromatic primary amines is reported. E.g., in presence of NaOH in toluene, N-alkylation of 2-aminobenzothiazole with 4-ClC6H4CH2OH gave 93% I. With 1 equiv of NaOH, N1,C5-dialkylation of 4-phenyl-2-aminothiazoles has been investigated. Reaction of in situ generated aldehyde with amine yields the N-alkylated and N1,C5-dialkylated products through hydride ion transformation from alc. In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Recommanded Product: 4,5-Diphenylthiazol-2-amine).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Recommanded Product: 4,5-Diphenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica