With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.
Example-4 Preparation of Febuxostat Potassium (IA-b) 3.7 N potassium hydroxide solution was added to a reaction mass of (50.0 g) 2-(4-isobutoxy-3-cyanophenyl)-4-methylthiazole-5-ethyl carboxylate in (250.0 ml) isopropyl alcohol. The reaction mixture was stirred and heated to get complete potassium salt of febuxostat. The febuxostat potassium was isolated by filtration. The moisture content of the said compound is 6.03percent. HPLC purity: >99percent The XRPD of potassium salt of febuxostat is attached as .
160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.
Reference£º
Patent; CADILA HEALTHCARE LIMITED; Dwivedi, Shriprakash Dhar; Prasad, Ashok; Roy, Rushikesh Udaykumar; Patel, Mayur Ramnikbhai; US2013/190366; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica