Relationship between structure and inhibiting action of derivatives of 2-aminothiazole was written by Voloshin, V. F.;Golosova, O. P.;Krasovskii, V. A.. And the article was included in Zashchita Metallov in 1986.Application of 6318-74-7 This article mentions the following:
The weight loss method was used to study the connection between the inhibiting action of derivatives of 2-aminothiazole and the nature of the substituent in its ring at their concentrations of 0.01M on steel St 3 [39296-41-8] in 10% solutions of HCl and H2SO4. At the same time, polarization measurements were made on Armco Fe samples pressed into Teflon as well as the impedance of the electrlyte/electrode interface at 25°. A correlation was observed between the pKa value and the logarithm of the inhibition factor (γ) and the corrosion rate (K) in g/(m2-h). The following inhibitors were studied: 2-amino-4,5-diphenylthiazole; 2-amino-4-phenyl-5-tert-butylthiazole; 2-amino-5-methylbenzothiazole; 2-amino-4-methyl-5-isopropylthiazole; 2-amino-4-methylthiazole; 2-amino-4,5-dimethylthiazole; 2-aminothiazole; and 2-amino-4-methyl-5-acetylthiazole. The high electron d. on the heteroatom of the inhibitor mol. is important, but is not the only condition for protective activity of the compound In the experiment, the researchers used many compounds, for example, 4,5-Diphenylthiazol-2-amine (cas: 6318-74-7Application of 6318-74-7).
4,5-Diphenylthiazol-2-amine (cas: 6318-74-7) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Application of 6318-74-7
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica