Thiomethylation and thiohydroxylation – a new pathway of metabolism of heterocyclic compounds was written by Pal, R.;Spiteller, G.. And the article was included in Xenobiotica in 1982.Reference of 20485-41-0 This article mentions the following:
Gas-liquid chromatog.-mass spectral anal. of thin-layer chromatog. fractions of urine samples from patients treated with clomethiazole (I) [533-45-9] revealed 2 minor metabolites formed by thiomethylation and thiohydroxylation, namely 2-methylthioclomethiazole [87764-52-1] and 5-acetyl-4-methyl-2-methylmercaptothiazole [73548-99-9], resp. The structures of 6 other minor metabolites resulting from side-chain degradation were also elucidated. The occurrence of metabolites with substituents at position 2 of the heterocyclic nucleus was assumed to be initiated by oxidative attack of the N, followed by nucleophilic substitution at position 2. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Reference of 20485-41-0).
4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazole is a five-membered, unsaturated, planar, π-excessive heteroaromatic containing one sulfur atom and one pyridine-type nitrogen atom at position 3 of the cyclic ring system. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 20485-41-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica