Diastereoselective and Enantioselective Silylation of 2-Arylcyclohexanols was written by Wang, Li;Akhani, Ravish K.;Wiskur, Sheryl L.. And the article was included in Organic Letters in 2015.Synthetic Route of C15H12N2S This article mentions the following:
The silylation-based kinetic resolution of trans 2-arylcyclohexanols was accomplished by employing a triaryl silyl chloride as the derivatizing reagent with a com. available isothiourea catalyst. The methodol. is selective for the trans diastereomer over the cis, which provides an opportunity to selectively derivatize one stereoisomer out of a mixture of four. By employing this technol., a facile, convenient method to form a highly enantiomerically enriched silylated alc. was accomplished through a 1-pot reduction-silylation sequence that started with a 2-aryl-substituted ketone. In the experiment, the researchers used many compounds, for example, (S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3Synthetic Route of C15H12N2S).
(S)-2-Phenyl-2,3-dihydrobenzo[d]imidazo[2,1-b]thiazole (cas: 950194-37-3) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Synthetic Route of C15H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica