Unexpected Intermolecular Pd-Catalyzed Cross-Coupling Reaction Employing Heteroaromatic Carboxylic Acids as Coupling Partners was written by Forgione, Pat;Brochu, Marie-Christine;St-Onge, Miguel;Thesen, Kris H.;Bailey, Murray D.;Bilodeau, Francois. And the article was included in Journal of the American Chemical Society in 2006.Name: 4-Methylthiazole-5-carboxylic acid This article mentions the following:
A palladium catalyzed decarboxylative cross-coupling reaction of five-membered heteroaromatic carboxylic acids with aryl bromides for preparing aryl-substituted heteroaromatics has been disclosed. The coupling on the carbon connecting carboxyl group is an attractive complement to the existing C-H functionalization method. In the experiment, the researchers used many compounds, for example, 4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0Name: 4-Methylthiazole-5-carboxylic acid).
4-Methylthiazole-5-carboxylic acid (cas: 20485-41-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Name: 4-Methylthiazole-5-carboxylic acid
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica