Biswajit, Das et al. published their research in American Journal of Pharmacy and Health Research in 2014 | CAS: 16595-80-5

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (cas: 16595-80-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 16595-80-5

An overview of levamisole hydrochloride with immuno-stimulant activity was written by Biswajit, Das;Suvakanta, Dash;Chandra, Choudhury Ramesh;Jashabir, Chakraborty. And the article was included in American Journal of Pharmacy and Health Research in 2014.Reference of 16595-80-5 This article mentions the following:

Levamisole, marketed as the hydrochloride salt under the trade name Ergamisol (R12564), is an anti helminthic and immunomodulator belonging to a class of synthetic imidazo-thiazole derivatives It was discovered in 1966 at Belgium’s Janssen pharmaceutica, where it was prepared initially in the form of its racemate called tetramisole. The two stereoisomers of tetramisole were subsequently synthesized, and the levorotatory isomer was given the name levamisole. Levamisole has been used in humans to treat parasitic worm infections, and has been studied in combination with other forms of chemotherapy for colon cancer, melanoma, and head and neck cancer. In some of the leukemic cell line studies, both levamisole and tetramisole showed similar effect. Effective studies need to be undertaken to study the full potential of levamisole in Immunostimulation activities and immuno synergestic effect of Levamisole with combination to natural polysaccharides. In the experiment, the researchers used many compounds, for example, (S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (cas: 16595-80-5Reference of 16595-80-5).

(S)-6-Phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole hydrochloride (cas: 16595-80-5) belongs to thiazole derivatives. The higher aromaticity of thiazole is due to delocalization of a lone pair of sulfur electrons across the ring, which is evidenced by chemical shifts of ring hydrogen at δ 7.27 and 8.77 ppm (C2 and C4), indicating diamagnetic ring current. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Reference of 16595-80-5

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica