Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening was written by Vom, Amelia;Headey, Stephen;Wang, Geqing;Capuano, Ben;Yuriev, Elizabeth;Scanlon, Martin J.;Simpson, Jamie S.. And the article was included in Australian Journal of Chemistry in 2013.Recommanded Product: 4-(2-Amino-4-thiazolyl)phenol This article mentions the following:
Aggregation of small organic compounds is a problem encountered in a variety of assay screening formats where it often results in detection of false positives. A saturation transfer difference-NMR-detected screen of a com. available fragment library, followed by biochem. assay, identified several inhibitors of the enzyme ketopantoate reductase. These inhibitors were subsequently revealed to be aggregation-based false positives. Modification of the fragment screen by addition of detergent in the saturation transfer difference-NMR experiments allowed an assay format to be developed that resulted in the identification of genuine hit mols. suitable for further development. In the experiment, the researchers used many compounds, for example, 4-(2-Amino-4-thiazolyl)phenol (cas: 57634-55-6Recommanded Product: 4-(2-Amino-4-thiazolyl)phenol).
4-(2-Amino-4-thiazolyl)phenol (cas: 57634-55-6) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Recommanded Product: 4-(2-Amino-4-thiazolyl)phenol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica