Metal sulfide: An efficient promoter for the synthesis of 2-mercaptobenzothiazoles from 2-haloanilines and carbon disulfide was written by Zhang, Tianmiao;Qin, Weijing;Zhu, Ning;Han, Limin;Wang, Liubo;Hong, Hailong. And the article was included in Synthetic Communications in 2017.Product Details of 80087-71-4 This article mentions the following:
A convenient method has been developed for the preparation of a variety of 2-mercaptobenzothiazoles from 2-haloanilines and CS2 mediated by metal sulfide. In this reaction, 2-haloanilines reacted with CS2 in the presence of Na2S·9H2O to form 2-mercaptobenzothiazoles. Na2S·9H2O functioned both as an activator of CS2 and as a base. Furthermore, NMR anal. was used to identify the different reaction mechanisms of 2-haloanilines and CS2 mediated by Na2S or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), which demonstrated that Na2S interacted only with CS2, while DBU reacted with both 2-iodoaniline and CS2. In the experiment, the researchers used many compounds, for example, 6-Fluorobenzo[d]thiazole-2(3H)-thione (cas: 80087-71-4Product Details of 80087-71-4).
6-Fluorobenzo[d]thiazole-2(3H)-thione (cas: 80087-71-4) belongs to thiazole derivatives. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.Product Details of 80087-71-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica