Electroorganic preparations. XVI. Polarography and reduction of quinazoline was written by Lund, Henning. And the article was included in Acta Chemica Scandinavica in 1965.Synthetic Route of C4H5BrN2S This article mentions the following:
The polarographic reduction of quinazoline (I) was observed throughout the pH range 0-12 and in more acid media (acidity function H+ to -2); 2 waves were observed. For the 1st wave the limiting current is diffusion controlled at pH 5 but is kinetically controlled at pH 1. The abnormal pH dependence of the limiting current can be explained by hydration of the protonated I nucleus if it is assumed that only the normal cation and not the hydrated cation is polarographically reducible. The rate constant of the dehydration was determined from polarographic data, and the dehydration was found to be specific acid catalyzed. The second wave of I is a reduction of the 3,4-dihydroquinazoline (II) formed in the first reduction at low concentrations of I. II was reduced in borate buffer to 1,2,3,4-tetrahydroquinazoline. I yields on controlled potential reduction both in acid and alk. solution a dimerized product, which probably is dimerized at C-4. The product can be reoxidized to I with hexacyanoferrate(III) in alk. solution In the experiment, the researchers used many compounds, for example, 2-Amino-5-bromo-4-methylthiazole (cas: 3034-57-9Synthetic Route of C4H5BrN2S).
2-Amino-5-bromo-4-methylthiazole (cas: 3034-57-9) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Synthetic Route of C4H5BrN2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica