Metal-free photo-induced sulfidation of aryl iodide and other chalcogenation was written by Mao, Shuai;Zhao, Yahao;Luo, Zixuan;Wang, Ruizhe;Yuan, Bo;Hu, Jianping;Hu, Linghao;Zhang, San-Qi;Ye, Xiaoxing;Wang, Mingliang;Chen, Zhengkai. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Synthetic Route of C7H9NS This article mentions the following:
A photo-induced C-S radical cross-coupling of aryl iodides and disulfides under transition-metal and external photosensitizer free conditions for the synthesis of aryl sulfides at room temperature has been presented, which features mild reaction conditions, broad substrate scope, high efficiency, and good functional group compatibility. The developed methodol. could be readily applied to forge C-S bond in the field of pharmaceutical and material science. In the experiment, the researchers used many compounds, for example, 4-(Methylthio)aniline (cas: 104-96-1Synthetic Route of C7H9NS).
4-(Methylthio)aniline (cas: 104-96-1) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Synthetic Route of C7H9NS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica