Design, synthesis and biological activity of tetrazole-bearing uric acid transporter 1 inhibitors was written by Cai, Wenqing;Liu, Wei;Xie, Yafei;Wu, Jingwei;Liu, Yuqiang;Liu, Changying;Xu, Weiren;Tang, Lida;Wang, Jianwu;Zhao, Guilong. And the article was included in Chemical Research in Chinese Universities in 2017.Category: thiazole This article mentions the following:
Systematic structure-activity relationship(SAR) exploration of a moderately active tetrazole-bearing lesinurad-based hit 1f led to the discovery of a potent uric acid transporter 1(URAT1) inhibitor 1i, which possessed a novel mol. skeleton and was 11-fold more potent than the parent lesinurad against human URAT1 in-vitro (IC50=0.66 μmol/L for 1i vs. 7.18 μmol/L for lesinurad). In the experiment, the researchers used many compounds, for example, 5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol (cas: 878671-96-6Category: thiazole).
5-Amino-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-thiol (cas: 878671-96-6) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Various laboratory methods exist for the organic synthesis of thiazoles. Prominent is the Hantzsch thiazole synthesis is a reaction between haloketones and thioamides.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica