Site-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones was written by Kudashev, Anton;Baudoin, Olivier. And the article was included in Chemistry – A European Journal in 2021.COA of Formula: C3H2BrNS This article mentions the following:
A ligand-controlled site-selective C(sp3)-H arylation of heteroaromatic ketones had been developed using Pd catalysis to gave ArC(O)CHR1CH2R2 [Ar = thiazol-2-yl, 2-pyridyl, 2-quinolyl, etc.; R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, Me, ph, etc.]. The reaction occurred selectively at the 伪- or 尾-position of the ketone side-chain. The switch from 伪- or 尾-arylation was realized by addition of a pyridone ligand. The 伪-arylation process showed broad scope and high site- and chemoselectivity, whereas the 尾-arylation was more limited. Mechanistic investigations suggested that 伪-arylation occurs through C-H activation/oxidative addition/reductive elimination whereas 尾-arylation involves desaturation and aryl insertion. In the experiment, the researchers used many compounds, for example, 2-Bromothiazole (cas: 3034-53-5COA of Formula: C3H2BrNS).
2-Bromothiazole (cas: 3034-53-5) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.Various laboratory methods exist for the organic synthesis of thiazoles. For example, 2,4-dimethylthiazole is synthesized from thioacetamide and chloroacetone.COA of Formula: C3H2BrNS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica