Heteroarylation of Sulfenate Ions In Situ Generated from 尾-Sulfinyl Esters under Transition-Metal-Free Conditions was written by Pilathottathil, Fathima;Unnikrishnan, Sreelakshmi;Kaliyamoorthy, Alagiri. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of 2-Chlorobenzothiazole This article mentions the following:
Heteroaryl sulfoxides are an integral part of several bioactive mols. and pharmaceuticals. A transition-metal-free route for the direct sulfinylation of 2-halobenzothiazoles and 2-halobenzimidazoles using 尾-sulfinyl esters as the source of the sulfenate ion in the presence of a Bronsted base such as LiOtBu, and the corresponding heteroaryl sulfoxides were isolated in yields of 30 to 94% have been described. Moreover, a plausible concerted nucleophilic aromatic substitution (cSNAr) pathway for the direct incorporation of sulfinyl functionality into the 2-haloheteroarenes has been hypothesized. In the experiment, the researchers used many compounds, for example, 2-Chlorobenzothiazole (cas: 615-20-3Quality Control of 2-Chlorobenzothiazole).
2-Chlorobenzothiazole (cas: 615-20-3) belongs to thiazole derivatives. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Quality Control of 2-Chlorobenzothiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica