Synthesis and in silico analysis of some new N-phosphorylated 1,2,4-triazole derivatives as potential mycocidal agents was written by Gumber, Khushbu;Sidhu, Anjali;Sharma, Vineet K.. And the article was included in Indian Journal of Heterocyclic Chemistry in 2017.Safety of 6-Fluorobenzo[d]thiazole-2(3H)-thione This article mentions the following:
Ten new biheterocyclic compounds were synthesized by two-step reaction protocol via formation of intermediate Ph phosphorodichloridate, followed by addition of triazole and the addnl. heterocyclic substituent to obtain the final product. The in vitro mycocidal potential of novel synthesized N-phosphorylated 1,2,4-triazole derivatives were examined on phytopathogens, namely, Blumeria graminis tritici, Puccinia striiformis, Puccinia triticina, and Ustilago tritici. Structure elucidation of the compounds was made on the basis of elemental anal., Fourier transform IR, 1H NMR, and 31P NMR spectral data. Most of the compounds with addnl. thiazole/benzothiazole moieties inflicted appreciable potential, comparable to standards and in silico anal. rationale the in vitro antifungal potential of the test compounds In the experiment, the researchers used many compounds, for example, 6-Fluorobenzo[d]thiazole-2(3H)-thione (cas: 80087-71-4Safety of 6-Fluorobenzo[d]thiazole-2(3H)-thione).
6-Fluorobenzo[d]thiazole-2(3H)-thione (cas: 80087-71-4) belongs to thiazole derivatives. Thiazoles frequently appear in peptide studies. Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis. Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.Safety of 6-Fluorobenzo[d]thiazole-2(3H)-thione
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica