Mathur, Neha et al. published their research in Chemical Science Transactions in 2016 | CAS: 15864-32-1

2-Amino-6-bromobenzothiazole (cas: 15864-32-1) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Formula: C7H5BrN2S

DNA – binding and cleavage studies of macrocyclic metal complexes containing heteroatomic ligands was written by Mathur, Neha;Bargotya, Sonlata. And the article was included in Chemical Science Transactions in 2016.Formula: C7H5BrN2S This article mentions the following:

Designing of improved metal complexes, irreversibly modifying the nucleic acids is important from chem. and biol. point of view. In this regard copper nucleases are of great significance, since they form an important class of artificial nucleases possessing biol. accessible redox potentials and high cleavage affinity. Therefore, they are potential reagents for cleavage of DNA. For the same, coordination compounds using Cu(II) surfactant with N and S donor ligands in a M:L (1:2) molar ratio, complexes Cu2(C15H31COO)4L2 and Cu2(C7H15COO)4L2 where L is 2-amino-6-bromobenzothiazole, were synthesized and fully characterized by elemental and spectral anal., 1H NMR, FTIR, ESR and mass spectra. The interaction of the complexes with Lactobacillus acidophilus DNA was studied using agarose gel electrophoresis measurements and visualization of cleavage pattern was done on a UV transilluminator. Results suggest the Cu(II) complexes bind to DNA via different modes. Gel electrophoresis study reveals the fact that the Cu complexes involving N and S donor moieties cleave super-coiled DNA to nicked linear forms. In the experiment, the researchers used many compounds, for example, 2-Amino-6-bromobenzothiazole (cas: 15864-32-1Formula: C7H5BrN2S).

2-Amino-6-bromobenzothiazole (cas: 15864-32-1) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Formula: C7H5BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica